Hedgehog Signal Transduction: Signal Integration and Cross Talk in Development and Cancer
نویسندگان
چکیده
منابع مشابه
Frontiers in hedgehog signal transduction.
The hedgehog (Hh) pathway is a paracrine cell–cell communicaion system discovered in Drosophila over thirty years ago and then tudied for its central role in development in both vertebrates and nvertebrates. Hh was later implicated in other processes, includng adult stem cell maintenance, cell migration, axon guidance and ancer, in a wide range of organisms. Its identification as an oncoenic dr...
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The Hedgehog (Hh) family of signaling molecules are key agents in patterning numerous types of tissues. Mutations in Hh and its downstream signaling molecules are also associated with numerous oncogenic and disease states. Consequently, understanding the mechanisms by which Hh signals are transduced is important for understanding both development and disease. Recent studies have clarified sever...
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We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activities for its partner RR. We show that by combining a small number of mutations in CpxA that individu...
متن کاملThe mechanism of hedgehog signal transduction.
Hedgehog (Hh) proteins are one of a small number of families of secreted signalling proteins that are responsible for cell interactions during development in many animals. As such, Hh signals produce many different responses at different times and in different cells. As for other multifunctional ligands, this requires regulated patterns of expression, special mechanisms for ligand movement betw...
متن کاملHedgehog signal transduction: from flies to vertebrates.
The patterning and morphogenesis of multicellular organisms require a complex interplay of inductive signals which control proliferation, growth arrest, and differentiation of different cell types. A number of such signaling molecules have been identified in vertebrates and invertebrates. The molecular dissection of these pathways demonstrated that in vertebrates, mutations or abnormals functio...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2006
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.5.15.3130